Objective To identify the effects of resistance training on bone mineral density in patients with postmenopausal osteopenia or osteoporosis using meta-analysis.Methods We performed a systematic search in PubMed,CINAHL,Embase,Web of Science,Wanfang,CNKI and CBM to collect studies about effects of resistance training on bone mineral density in patients with postmenopausal osteopenia or osteoporosis published from inception to April 2019. Meta-analysis was performed using RevMan 5.3 software after two independent reviewers conducted independent literature screening,data extraction,and literature quality evaluation according to inclusion and exclusion criteria.Results Seven studies were recruited,including 698 cases. The results of meta-analysis showed that resistance training had a positive effect on bone mineral density at the lumbar spine in patients with postmenopausal osteopenia or osteoporosis compared with conventional exercise. The combined effect was statistically significant[MD=0.02,95%CI（0.00,0.05）,P=0.04]. Resistance training had no significant effect on bone mineral density at the femoral neck[MD=0.01,95%CI（-0.00,0.02）,P=0.17],hip[MD=0.01,95%CI（-0.01,0.02）,P=0.41],greater tro-chanter[MD=0.01,95%CI（-0.00,0.03）,P=0.16]and serum osteocalcin[MD=1.44.95%CI（-2.23,5.12）,P=0.44].Conclusion Resistance training significantly improved bone mineral density in the lumbar spine,but did not improve bone mineral density in the femoral neck,hip,greater trochanter and serum osteocalcin in patients with postmenopausal osteopenia or osteoporosis. At present,there is insufficient evidence for the effects of resistance training on bone mineral density in patients with postmenopausal osteopenia or osteoporosis,the sample size varies greatly,and more high-quality studies are needed for future research.
